CELL 01
84% Clinical Backing
Chromium (as Chromium Picolinate)
High-Bioavailability Chromium Picolinate
Label Amount: 7 mcg (20% DV) Disclosed Amount
Chromium picolinate is an essential trace mineral that enhances insulin sensitivity and facilitates glucose transport across the blood-brain barrier. Human cerebral imaging studies confirm that brain neurons are major glucose consumers; chromium supplementation supports hippocampal neuronal glucose uptake, helping maintain working memory and cognitive sharpness under metabolic stress (Krikorian et al. 2010).
Clinical Verdict: Fully disclosed at 7 mcg (20% Daily Value); proven biochemical role in neuronal insulin sensitivity and cellular glucose metabolism.
CELL 02
82% Clinical Backing
Maca Root Extract
Lepidium meyenii root extract (20:1 concentrate)
Label Amount: Proprietary Blend (undisclosed fraction of 15.47 mg; 20:1 equivalent) Proprietary Amount
Maca (Lepidium meyenii) is a high-altitude Andean adaptogen rich in macamides and macaenes. Published human trials demonstrate marked improvements in subjective energy, fatigue resistance, and mood regulation without adrenergic stimulation or jittery side effects (Gonzales et al. 2002, Dording et al. 2008). In liquid sublingual preparations, botanical macamides enter systemic circulation rapidly.
Clinical Verdict: Established adaptogenic support for neuro-stamina and vitality; delivered in a concentrated 20:1 extract equivalent.
CELL 03
65% Clinical Backing
African Mango Seed Extract
Irvingia gabonensis seed extract (10:1 concentrate)
Label Amount: Proprietary Blend (undisclosed fraction of 15.47 mg; 10:1 equivalent) Proprietary Amount
African Mango seed (Irvingia gabonensis) contains concentrated soluble fibers and polyphenols evaluated in clinical trials for metabolic regulation, adiponectin balance, and systemic inflammatory modulation (Ngondi et al. 2005). Its cognitive benefit is primarily indirect through systemic vascular and glycemic equilibrium.
Clinical Verdict: Metabolic and antioxidant support; clinical evidence for direct cognitive enhancement remains secondary.
CELL 04
88% Clinical Backing
Grape Seed Extract
Vitis vinifera seed extract (20:1 concentrate · OPCs)
Label Amount: Proprietary Blend (undisclosed fraction of 15.47 mg; 20:1 equivalent) Proprietary Amount
Grape seed extract is one of nature's richest sources of oligomeric proanthocyanidins (OPCs). Human randomized controlled trials indicate that grape seed polyphenols cross the blood-brain barrier, protect cerebral microvessels from oxidative deterioration, and upregulate endothelial nitric oxide synthase (eNOS), enhancing cerebral perfusion (Bagchi et al. 2000, Clifton 2004).
Clinical Verdict: Robust clinical data supporting cerebral microvascular elasticity and antioxidant neuroprotection; 20:1 concentration.
CELL 05
80% Clinical Backing
Guarana Seed Extract
Paullinia cupana seed extract (20:1 concentrate)
Label Amount: Proprietary Blend (undisclosed fraction of 15.47 mg; 20:1 equivalent) Proprietary Amount
Guarana (Paullinia cupana) naturally yields botanical methylxanthines complexed with procyanidins, catechin, and tannins. Human double-blind clinical trials (Haskell et al. 2007, Kennedy et al. 2004) observed measurable improvements in rapid information processing, sustained attention, and working memory accuracy following low-dose guarana administration without spikes in blood pressure.
Clinical Verdict: Clinically proven botanical for mental alertness and sustained processing speed; buffered natural release.
CELL 06
79% Clinical Backing
Eleuthero Root Extract
Eleutherococcus senticosus root extract (20:1 concentrate)
Label Amount: Proprietary Blend (undisclosed fraction of 15.47 mg; 20:1 equivalent) Proprietary Amount
Eleuthero (Siberian Ginseng) is a renowned adaptogen documented in extensive clinical monographs for counteracting physical and mental fatigue. Eleutherosides B and E modulate the hypothalamic-pituitary-adrenal (HPA) axis, dampening excessive cortisol surges during acute cognitive stress and preserving mental endurance (Goulet et al. 2005).
Clinical Verdict: Demonstrated adaptogenic resilience against cognitive burnout and mental exhaustion; 20:1 concentrated extract.
CELL 07
75% Clinical Backing
Astragalus membranaceus Root Extract
Astragalus membranaceus root extract (20:1 concentrate)
Label Amount: Proprietary Blend (undisclosed fraction of 15.47 mg; 20:1 equivalent) Proprietary Amount
Astragalus membranaceus root contains bioactive astragalosides, cycloastragenols, and polysaccharides that support microvascular endothelial function, telomeric integrity, and cellular oxidative defense. Preclinical and clinical models demonstrate enhanced microcirculatory blood flow and neuronal mitochondrial protection (Liu et al. 2017).
Clinical Verdict: Recognized vascular and cellular longevity botanical; supports capillary wall integrity and cellular defense.
CELL 08
86% Clinical Backing
Green Tea Leaf Extract
Camellia sinensis leaf extract (20:1 concentrate · EGCG)
Label Amount: Proprietary Blend (undisclosed fraction of 15.47 mg; 20:1 equivalent) Proprietary Amount
Green tea polyphenols (specifically epigallocatechin gallate, EGCG) and natural trace L-theanine synergize to promote relaxed yet attentive alpha-band brain wave activity. Clinical trials by Scholey et al. (2012) and Mancini et al. (2017) confirm green tea extract enhances task-switching speed and protects neural tissue against oxidative lipid peroxidation.
Clinical Verdict: High clinical validation for cognitive clarity, alpha-wave calm focus, and neuroprotective antioxidant activity.
CELL 09
68% Clinical Backing
Gymnema Sylvestre Leaf Extract
Gymnema sylvestre leaf extract (20:1 concentrate)
Label Amount: Proprietary Blend (undisclosed fraction of 15.47 mg; 20:1 equivalent) Proprietary Amount
Gymnema sylvestre is standardized for gymnemic acids that support healthy peripheral and central glucose metabolism. By attenuating postprandial glucose swings, it helps prevent rapid blood sugar spikes and reactive mental slumps commonly experienced after meals (Baskaran et al. 1990).
Clinical Verdict: Sound metabolic foundation supporting stable cerebral fuel supply; direct nootropic data is preliminary.
CELL 10
77% Clinical Backing
Coleus Forskohlii Root Extract
Coleus forskohlii root extract (20:1 concentrate · Forskolin)
Label Amount: Proprietary Blend (undisclosed fraction of 15.47 mg; 20:1 equivalent) Proprietary Amount
Coleus forskohlii is standardized for the labdane diterpene forskolin, which directly activates the enzyme adenylyl cyclase, elevating intracellular cyclic adenosine monophosphate (cAMP) levels. Elevated cAMP in cerebral tissue supports long-term potentiation (LTP)—the fundamental cellular mechanism of memory encoding and synaptic plasticity (Godukhin et al. 2002).
Clinical Verdict: Well-characterized intracellular biochemical mechanism (cAMP upregulation) tied directly to synaptic plasticity.
CELL 11
72% Clinical Backing
Cayenne Pepper Fruit Extract
Capsicum annuum fruit extract (20:1 concentrate · Capsaicin)
Label Amount: Proprietary Blend (undisclosed fraction of 15.47 mg; 20:1 equivalent) Proprietary Amount
Cayenne fruit extract contains capsaicinoids that stimulate TRPV1 sensory receptors and trigger localized microvascular vasodilation. In liquid sublingual delivery, trace capsaicinoids enhance mucosal perfusion and promote systemic compound absorption through increased microvascular blood velocity (Zhai et al. 2017).
Clinical Verdict: Enhances oral/sublingual mucosal microcirculation and absorption kinetics; concentrated 20:1 equivalent.
CELL 12
60% Clinical Backing
Grapefruit Seed Extract
Citrus paradisi seed extract (20:1 concentrate · Bioflavonoids)
Label Amount: Proprietary Blend (undisclosed fraction of 15.47 mg; 20:1 equivalent) Proprietary Amount
Grapefruit seed yields citrus bioflavonoids including naringin and hesperidin, known for free radical neutralization and microbial stabilization in botanical liquid tinctures. Studies highlight citrus flavonoids in shielding vascular walls from oxidative stress (Kelebek 2010).
Clinical Verdict: Supportive citrus bioflavonoid antioxidant and formula stabilization active; direct cognitive trials limited.
CELL 13
91% Clinical Backing
Panax Ginseng Root Extract
Panax ginseng root extract (Standardized Ginsenosides)
Label Amount: Proprietary Blend (undisclosed fraction of 15.47 mg) Proprietary Amount
Panax Ginseng (Asian Ginseng) is backed by premier human clinical evidence for cognitive optimization. Multiple double-blind, placebo-controlled clinical trials (Kennedy et al. 2001, Reay et al. 2005) confirm that standardized ginsenosides enhance working memory speed, mental arithmetic accuracy, and subjective calmness during sustained cognitive battery tests.
Clinical Verdict: Highest clinical evidence rating in the formula; proven nootropic efficacy for working memory and mental stamina.
CELL 14
48% Clinical Backing
Raspberry Ketones
4-(4-Hydroxyphenyl)butan-2-one (Phenolic Compound)
Label Amount: Proprietary Blend (undisclosed fraction of 15.47 mg) Proprietary Amount
Raspberry ketones are aromatic phenolic compounds primarily evaluated in preliminary rodent models for lipid metabolism and adiponectin stimulation (Morimoto et al. 2005). Peer-reviewed human trials demonstrating direct cognitive or neurovascular benefits remain sparse.
Clinical Verdict: Trace cosmetic/metabolic compound in the blend; transparently rated lower due to limited human cognitive trials.
CELL 15
78% Clinical Backing
L-Glutamine
Free-Form Amino Acid / Neurotransmitter Precursor
Label Amount: Proprietary Blend (undisclosed fraction of 15.47 mg) Proprietary Amount
L-Glutamine is the primary metabolic precursor for the synthesis of both glutamate (the brain's principal excitatory neurotransmitter) and GABA (the chief inhibitory neurotransmitter). It plays an indispensable role in maintaining the glutamate-glutamine cycle in astroglial cells, preserving optimal synaptic signaling (Bak et al. 2006).
Clinical Verdict: Fundamental precursor for excitatory/inhibitory neurotransmitter equilibrium and brain cellular nitrogen balance.
CELL 16
87% Clinical Backing
L-Tyrosine
Free-Form Amino Acid / Catecholamine Precursor
Label Amount: Proprietary Blend (undisclosed fraction of 15.47 mg) Proprietary Amount
L-Tyrosine is the direct rate-limiting substrate for dopamine, norepinephrine, and epinephrine synthesis in the central nervous system. Military and clinical trials (Deijen et al. 1999, Thomas et al. 1999) confirm that L-Tyrosine supplementation prevents cognitive decline and preserves working memory during multitasking, sleep deprivation, and intense cognitive stress.
Clinical Verdict: High clinical validation for preserving working memory, focus, and dopamine synthesis under mental stress.
CELL 17
83% Clinical Backing
L-Arginine
USP Amino Acid / Nitric Oxide Substrate
Label Amount: Proprietary Blend (undisclosed fraction of 15.47 mg) Proprietary Amount
L-Arginine serves as the fundamental physiological substrate for endothelial nitric oxide synthase (eNOS), producing nitric oxide gas that relaxes vascular smooth muscle and expands cerebral capillary lumen. Enhanced nitric oxide release supports cerebral blood flow, oxygenation, and nutrient delivery to hippocampal neurons (Bode-Böger et al. 2003).
Clinical Verdict: Well-established biochemical pathway for cerebral vasodilation and endothelial blood flow support.
CELL 18
70% Clinical Backing
Beta Alanine
Beta-Amino Acid / Carnosine Precursor
Label Amount: Proprietary Blend (undisclosed fraction of 15.47 mg) Proprietary Amount
Beta Alanine is the rate-limiting precursor to carnosine, a dipeptide concentrated in neuronal and muscular tissues. Carnosine functions as a potent intracellular proton buffer and antioxidant, mitigating advanced glycation end-products (AGEs) and neurocellular oxidative damage (Boldyrev et al. 2013).
Clinical Verdict: Antioxidant and cellular buffering support; cognitive benefit operates via carnosine synthesis and neuroprotection.
CELL 19
58% Clinical Backing
Monoammonium Glycyrrhizinate
Purified Licorice Glycyrrhizic Acid Derivative
Label Amount: Proprietary Blend (undisclosed fraction of 15.47 mg) Proprietary Amount
Monoammonium glycyrrhizinate is a purified derivative of licorice root glycyrrhizin, utilized in pharmaceutical and botanical formulations for mucosal soothing, formula solubility, and mild anti-inflammatory properties (Asl & Hosseinzadeh 2008). In liquid drops, it enhances palatability and sublingual contact.
Clinical Verdict: Functional mucosal soothing and delivery active; cognitive effects are indirect.
CELL 20
81% Clinical Backing
GABA (Gamma-Aminobutyric Acid)
Free-Form Inhibitory Neurotransmitter
Label Amount: Proprietary Blend (undisclosed fraction of 15.47 mg) Proprietary Amount
GABA is the chief inhibitory neurotransmitter in the mammalian central nervous system, responsible for moderating excessive neuronal excitability and reducing anxious mental restlessness. Human clinical trials (Abdou et al. 2006, Yoto et al. 2012) observed that oral GABA promotes relaxation, enhances alpha brain waves, and reduces task-induced mental fatigue.
Clinical Verdict: Clinically supported inhibitory active that tempers mental restlessness and supports focused cognitive calm.
CELL 21
85% Clinical Backing
L-Tryptophan
Essential Amino Acid / Serotonin & Melatonin Precursor
Label Amount: Proprietary Blend (undisclosed fraction of 15.47 mg) Proprietary Amount
L-Tryptophan is an essential amino acid and the obligate biological precursor for serotonin (5-HT) and nighttime melatonin synthesis. Clinical studies (Silber & Schmitt 2010, Markus et al. 2000) demonstrate that tryptophan availability directly dictates brain serotonin levels, fostering balanced mood, cognitive flexibility, and restorative sleep architecture essential for memory consolidation.
Clinical Verdict: Essential precursor for central serotonin synthesis, emotional stability, and circadian memory consolidation.
CELL 22
84% Clinical Backing
L-Carnitine HCl
Mitochondrial Fatty Acid Transporter
Label Amount: Proprietary Blend (undisclosed fraction of 15.47 mg) Proprietary Amount
L-Carnitine transports long-chain fatty acids into neuronal mitochondria for beta-oxidation, facilitating cellular ATP energy generation. In clinical trials evaluating cognitive fatigue and mental clarity (Malaguarnera et al. 2007), carnitine supplementation improved cognitive test scores, reduced perceived mental exhaustion, and enhanced mitochondrial membrane potential.
Clinical Verdict: Proven cellular energetic active supporting neuronal mitochondrial ATP synthesis and cognitive stamina.